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KMID : 0545120200300050649
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 5 p.649 ~ p.661
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Laxative Activity of the Hot-Water Extract Mixture of Hovenia dulcis Thunb. and Phyllostachys pubescens Mazel in Chronic Constipation Model SD Rats
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Oh Kyo-Nyeo
Kim Yu-Jin
Choi Eun-Jin
Lee Hyun-Mi
Hong Ji-Ae
Kim Mi-Ri
Oh Dool-Ri
Jung Myung-A
Park Ro-Dong
Kim Seong-Il
Yong Ju-Seon
Lee Hui-Seop
Ban Sang-Oh
Choi Chul-Yung
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Abstract
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This study examined the laxative effects of hot-water extracts of Hovenia dulcis Thunb. (HD), Phyllostachys pubescens Mazel (PM), and a 2:8 mixture of both (HP) in two chronic constipation models. For the loperamide-induced constipation model, animals were divided into an untreated group, negative control group (loperamide 4 mg/kg), positive control group (bisacodyl 4 mg/kg) group, and six treatment groups (HP 100 or 400, HD 50 or 100, and PM 100 or 400 mg/kg). For the lowfiber diet-induced constipation model, animals were divided into an untreated group (normal diet), negative control group (low-fiber diet), positive control group (Agio granule, 620 mg/kg), and the same treatment groups. Fecal number, weight, fecal water content, and intestinal transit ratio were higher in the groups treated with HP, HD, and PM than in the groups treated with loperamide or lowfiber diet. Thickness of colon mucosa and muscle layers were increased in the treated groups. Colon tension increased in the HP groups, and [Ca2+]i measurements using fura-2 as an indicator showed that HP inhibits ATP-mediated Ca2+ influx in IEC-18 cells. These results showed that the HP mixture has laxative activity by increased mucin secretion and inducing contractile activity and relaxation. It may be a useful therapeutic strategy for ameliorating in chronic constipation.
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KEYWORD
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Constipation, Hovenia dulcis Thunb., laxative activity, Ca2+ influx, Phyllostachys pubescens Mazel
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